Absorbed from the gastrointestinal tract, bioavailability – 89%. The equilibrium concentrations are reached within 3 – 5 days. Binding to plasma proteins – 99%. It penetrates through the blood-tissue barriers. Almost completely metabolized in the liver. Deca durabolin for sale. Plasma clearance – 8 ml / min, the elderly decreases.
– osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (ankylosing spondylitis)
– elimination of pain and inflammation in degenerative and inflammatory joint diseases (including acute attack of gouty arthritis)
– lumbago, sciatica, neuralgia, myalgia, diseases of extra-articular and soft tissue, post-traumatic and post-operative pain
Dosing and Administration
The drug is taken orally during a meal once a day.
The recommended dosing regimen
– Rheumatoid arthritis: 15 mg / day. Depending on the therapeutic effect, the dose can be reduced to 7.5 mg / day.
– Osteoarthritis: 7.5 mg / day. . If necessary, the dose may be increased to 15 mg / day
– Ankylosing spondylitis: 15 mg / day.
The maximum recommended daily dose – 15 mg.
In patients with an increased risk of side effects, as well as in patients with severe renal impairment on hemodialysis, the dose should not exceed 7.5 mg / day.
– hypersensitivity to the drug
– aspirin-induced asthma
– the aggravation of gastric ulcer and duodenal ulcer
– gastrointestinal, deca durabolin for sale cerebrovascular or other bleeding
– severe hepatic, cardiac, renal failure (without dialysis)
– under 15 years
– Pregnancy, lactation
Side effects – diarrhea disorders, gastro – intestinal bleeding;
– headache, dizziness, disorientation
Interaction with other drugs
With simultaneous use of:
– other NSAIDs – increased risk of erosive and ulcerative lesions and gastrointestinal bleeding
– with antihypertensive drugs – may decrease the effectiveness of the latter
– with drugs lithium – can increase its toxic effect
– with methotrexate – increased side effects the latter on the hematopoietic system (risk of anemia and leukopenia)
– diuretics and cyclosporine – increase the risk of kidney failure
– with intrauterine contraceptives – may reduce the effectiveness of the past
– with anticoagulants and thrombolytics – increase the risk of bleeding
– To apply caution in patients with gastric ulcer and duodenal ulcer in the anamnesis, as well as receiving anticoagulant therapy, because of an increased risk of ulcerative erosive gastrointestinal diseases
– Monitor renal function when using the drug in elderly patients with chronic heart failure, liver cirrhosis, and in patients who have undergone surgery, which led to hypovolemia
– When assigning deca durabolin for sale simultaneously with diuretics, you should take plenty of fluids
– like other NSAIDs, may mask the symptoms of infectious diseases buy anabolic steroids online bruce lee’s workout anabolic steroids online uk