Menopur is a preparation of human menopausal gonadotropin high purity. The drug belongs to the group menotropinov comprises follicle stimulating and luteinizing hormones in the ratio 1: 1, obtained by extraction from the urine of women during menopause. Women Menopur stimulates the growth deca durabolin results and maturation of ovarian follicles, increases the level of estrogen stimulates endometrial proliferation. Men Menopur stimulates spermatogenesis acting on Sertoli cells of the seminiferous tubules. Pharmacokinetics. The maximum level of FSH in the blood plasma achieved through 6-24 hours after the / m introduction Menopur drug. Thereafter, the concentration of FSH in the blood is gradually lowered. The half-life of gonadotropins – 4-12 hours.
Indications for use. In women:
- infertility, caused hypothalamic-pituitary disorders (in order to stimulate the growth of a single dominant follicle);
- during assisted reproductive techniques for the offensive conception (stimulation of growth of multiple follicles).
- stimulation of spermatogenesis in azoospermia or oligoastenospermii – caused by primary or secondary hypogonadotropic hypogonadism (in combination with human chorionic gonadotropin therapy, such as drug ® ).
- persistent enlargement of the ovaries or the occurrence of ovarian cysts are not caused by polycystic ovary syndrome;
- anomalies of the genital or uterine fibroids incompatible with pregnancy;
- vaginal bleeding of unknown etiology;
- ovarian cancer, uterine or breast cancer;
- primary ovarian failure;
- prostate cancer or any other cancer in men androgenozavisimye;
- diseases of the thyroid and adrenal glands;
- tumors of the hypothalamic-pituitary region; hyperprolactinemia;
- Hypersensitivity to menotropinam (preparations containing luteinizing and / or follicle stimulating hormone) and the other ingredients of the formulation;
Dosing and Administration
Menopur is introduced into / m or subcutaneously. The solution for injection is prepared immediately prior to administration, using the supplied solvent. Unless indicated otherwise, the following regimen is recommended.
Use in Women
With infertility, caused hypothalamic-pituitary disorders, in order to stimulate the growth of the dominant follicle dose set individually.
The optimal dose and duration of treatment set on the basis of ultrasound examination of the ovaries, determining the level of estrogen in the blood, as well as clinical observation. About follicular maturation is judged to increase the level of estrogen in the blood.
Treatment is usually started with a dose of 75-150 ME (1-2 ampoules Menopur drug) per day. In the absence of ovarian response, the dose is gradually increased until the registration increase in blood-estrogen or growth of follicles. This dose is stored until the concentration reaches the preovulatory estrogen levels. With the rapid rise in estrogen levels at the beginning of stimulation dose should be reduced.
In order to induce ovulation in 1-2 days after the last injection, hMG is administered once 5.000-10.000 ME hCG.
Use in Men
With the purpose of stimulation of spermatogenesis are administered hCG 1.000-3.000 ME 3 times a week, until the normalization of testosterone levels in the blood. Thereafter, for several months, 3 times per week administered for the drug deca durabolin results.
Side effects are part of the endocrine system: mastalgia, a sharp increase in the excretion of estrogen in the urine, in men – genikomastiya. On the part of the ovary: mild (uncomplicated) enlargement of the ovaries and the formation of ovarian cysts. Ovarian hyperstimulation syndrome: severe pain in the abdomen, nausea, vomiting, increased body weight (early signs); hypovolemia, hemoconcentration (increase in the number of erythrocytes in plasma associated with a decrease in plasma volume), electrolyte imbalance, ascites, gemoperitonium (presence of blood in the abdominal cavity), hydrothorax, thromboembolic syndrome. Allergic and immunopathological reactions: arthralgia, hypersensitivity reactions occur rarely (fever, skin rash). Local: pain, redness, swelling, or itching at the injection site. On the part of the digestive tract: sometimes there may be nausea, vomiting, colicky pain. Others: oliguria, reduced blood pressure, increased body mass index, a multiple pregnancy. In very rare cases, long-term use of the drug, the formation of antibodies, which reduces the effectiveness of the therapy.
Currently, the cases of drug overdose Menopur were reported.
. Interaction with other drugs
Menopur may be used in combination with a drug Horagon ® (human chorionic gonadotropin, hCG) in women – to induce ovulation after follicular growth stimulation in men – to stimulate spermatogenesis.
. Special instructions
Before starting treatment with recommended appropriate treatment of hypothyroidism, adrenal insufficiency, hyperprolactinemia, tumors of the pituitary or hypothalamus, correction hemoconcentration.
Must assess the condition of the ovaries before the appointment praparata Menopur: ultrasound examination, the level of estradiol in the blood.
During the course of treatment, these studies It must be carried out every day or every other day. Careful observation of the patient’s condition -. An integral part of the treatment
of drug treatment of human menopausal gonadotropin (hMG) can often lead to ovarian hyperstimulation, which becomes clinically -vyrazhennoy after administration with the aim of ovulation drugs hCG (human chorionic gonadotropin) and is manifested in the formation of large ovarian cysts size. This is combined with the accumulation of fluid in the abdomen (ascites), pleural cavity (hydrothorax), and is accompanied by a decrease in urine output (oliguria), decreased blood pressure (hypotension) and blockage of blood vessels (thromboembolic phenomenon).
At the first signs of hyperstimulation: pain abdominal palpable physician or determined by ultrasound volumetric formation in the abdomen – treatment should be discontinued immediately!
In the presence of pregnancy, the above symptoms hyperstimulation syndrome aggravated, increasing the duration of their symptoms and this condition can lead to a threat to the life of the patient.
In cases of hyperstimulation should not be given the drug human chorionic gonadotropin (hCG) for ovulation.
in the treatment of hMG preparations often develops multiple pregnancy.
in men with high blood deca durabolin results levels of FSH (indicating primary testicular failure) Menopur is usually ineffective.
. Product form vial: 75 ME N + 75 ME FSH colorless vial of glass type I with a rubber stopper, an aluminum run and a plastic cap-type “flip-off”. The ampoule with the solvent: 1 ml in colorless glass vials of 1 ml of glass type I with the possible application of colored dots and / or one or two colored rings. at 5 5 vials of drug and solvent ampoules in one cardboard or plastic cellular packaging, one or two stripes package in a carton box with instructions for use. steroids for flu oxavar buy steroids