The active substance is obtained from the urine of women in the postmenopausal period. In women menogon ® causes an increase in the level of estrogen in the blood, and the maturation of the egg, in men – activates the production of testosterone and sperm production. The maximum level of FSH in the blood plasma achieved through 6-48 hours after intramuscular after administration and 6-36 hours after subcutaneous administration. Thereafter, the concentration of FSH in the blood is gradually reduced with a half-life 56 hours (intramuscular administration) and 51 hours what is deca durabolin (subcutaneous administration).
- female infertility associated with impaired follicular maturation process, against the background of hypo- and normogonadotropic ovarian failure;
- induction of ovulation in conjunction with the preparation of hCG;
- male infertility associated with impaired spermatogenesis in the background of hypo- and normogonadotropic hypogonadism in conjunction with the preparation of hCG.
Use strictly on prescription!Contraindications
: Hypersensitivity to the drug and solvent.
- pregnancy, lactation;
- the presence of cysts or enlargement of the ovaries size not related to polycystic ovarian syndrome;
- tumors of the hypothalamic-pituitary region;
- diseases of the thyroid and adrenal glands;
- polycystic ovary syndrome;
- abnormal development of reproductive organs (incompatible with normal pregnancy);
- uterine fibroids;
- metrorrhagia (unknown etiology);
- estrogen dependent tumor (cancer of the ovaries, uterus, mammary gland);
- primary ovarian failure;
- prostate cancer;
- androgen tumor.
If you have one of these diseases, before taking this medication, you should consult with your doctor.Precautions see. section “Special instructions”.
Pregnancy and breast-feeding
Use of the drug is contraindicated during pregnancy and lactation.
Dosing and Administration
The drug menogon ® is administered intramuscularly or subcutaneously after dissolving in the accompanying solvent. The following regimens are recommended: In women with a view to stimulating the growth of follicles dose is selected individually depending on the ovarian response and is adjusted according to the results of ultrasound and the level of estrogen in the blood. When excessive dose of hMG preparation observed multiple single- or double-sided growth of the follicles. Treatment is usually started with a dose of 75-150 ME (1-2 ampoules of the drug menogon ® ) per day. In the absence of ovarian response, the dose is gradually increased to enhance the registration of blood estrogen or follicular growth. This dose is stored until the concentration reaches the preovulatory estrogen levels. With the rapid rise in estrogen levels at the beginning of stimulation, hMG dose should be reduced. In order to induce ovulation in 1-2 days after the last injection of hMG, once introduced 5.000-10.000 ME hCG. In men, in order to stimulate spermatogenesis administered by 1.000-3.000 ME hCG three times per week until the normalization of testosterone levels in the blood. Thereafter, for several months, 3 times per week administered drug menogon ® at 75-150 ME (1-2 ampoules).
- Treatment with drugs hMG can lead to hyperstimulation of the ovaries, which clinically manifested after the appointment, the purpose of ovulation, human chorionic gonadotropin (hCG). This can lead to the formation of ovarian cysts larger the risk of rupture and the occurrence of abdominal bleeding. Furthermore, in severe ovarian hyperstimulation may also occur:. Ascites, hydrothorax, oliguria, hypotension and phenomena thromboembolism
. With prolonged use what is deca durabolin of the drug, in rare cases, the formation of antibodies, which leads to inefficiency therapy
If any of these instructions adverse effects compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.
of ovarian hyperstimulation:
– hyperstimulation 1 degree – easy – does not require treatment, accompanied by a slight increase in the size of the ovaries (5-7 cm), high levels of sex steroids and abdominal pain. The patient should be informed about her condition and carefully monitored.
– Hyperstimulation 2 degree – requires hospitalization and symptomatic treatment including intravenous infusion – solutions for maintaining bcc (in case of increase in hemoglobin concentration). Ovarian cysts the size of 8-10 cm are accompanied by abdominal symptoms, nausea and vomiting.
– 3 degrees for hyperstimulation characterized by cysts ovary the size of 10 cm or more, ascites, hydrothorax, and an increase in abdominal pain, dyspnea, salt retention, increase in hemoglobin concentration blood and increase its viscosity, accompanied by increased platelet adhesion to the risk of thromboembolism. It requires mandatory hospitalization.
The interaction with other drugs
. Not described
menogon ® may be used in combination with a preparation of human chorionic gonadotropin (hCG) in women – to induce ovulation after stimulation of follicular growth in men -. To stimulate spermatogenesisdrug should not confuse one syringe with other drugs!
Treatment should be under the supervision of a physician with experience in treating infertility!
Before starting the treatment of infertility in women should assess the functional state of the ovaries (ultrasound and estradiol levels in the blood plasma). During treatment, these studies should be carried out every day or every other day of the appearance of reaction that can be evaluated for cervical index (evaluation of the quality of cervical mucus). Careful observation of the patient’s condition is necessary for the entire course of treatment.
- At the first sign of ovarian hyperstimulation syndrome (abdominal pain and palpable doctor or determined by ultrasound increased education in the abdomen), treatment should be stopped immediately!
- In the case of ovarian hyperstimulation syndrome to enter ovulatory dose of hCG is contraindicated! In the case of pregnancy, symptoms of excessive hyperstimulation may increase and observed for a long time, as a threat to the life of the patient.
- Often, multiple pregnancy develops in the treatment of drug hMG.
Before the appointment of the drug menogon ® is necessary to conduct appropriate treatment in disorders of the thyroid gland or the adrenal cortex, hyperprolactinemia of different etiology, tumor hypothalamic-pituitary region.
In the period of treatment in men with a high concentration in the blood FSH menotropiny ineffective . The what is deca durabolin effect on the ability to drive and use machinery None.